http://purl.uniprot.org/citations/23296215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/23296215 | http://www.w3.org/2000/01/rdf-schema#comment | "AimsThe life-time drinking profiles of Japanese alcoholics have shown that gastrectomy increases susceptibility to alcoholism. We investigated the trends in gastrectomy and alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) genotypes and their interactions in alcoholics.MethodsThis survey was conducted on 4879 Japanese alcoholic men 40 years of age or older who underwent routine gastrointestinal endoscopic screening during the period 1996-2010. ADH1B/ALDH2 genotyping was performed in 3702 patients.ResultsA history of gastrectomy was found in 508 (10.4%) patients. The reason for the gastrectomy was peptic ulcer in 317 patients and gastric cancer in 187 patients. The frequency of gastrectomy had gradually decreased from 13.3% in 1996-2000 to 10.5% in 2001-2005 and to 7.8% in 2006-2010 (P < 0.0001). ADH1B*1/*1 was less frequent in the gastrectomy group than in the non-gastrectomy group (age-adjusted prevalence: 20.4 vs. 27.6%, P = 0.006). ALDH2 genotype distribution did not differ between the two groups. The frequency of inactive ALDH2*1/*2 heterozygotes increased slightly from 13.0% in 1996-2000 to 14.0% in 2001-2005 and to 15.4% in 2006-2010 (P < 0.08). Two alcoholism-susceptibility genotypes, ADH1B*1/*1 and ALDH2*1/*1, modestly but significantly tended not to occur in the same individual (P = 0.026). The frequency of ADH1B*1/*1 decreased with ascending age groups.ConclusionsThe high frequency of history of gastrectomy suggested that gastrectomy is still a risk factor for alcoholism, although the percentage decreased during the period. The alcoholism-susceptibility genotype ADH1B*1/*1 was less frequent in the gastrectomy group, suggesting a competitive gene-gastrectomy interaction for alcoholism. A gene-gene interaction and gene-age interactions regarding the ADH1B genotype were observed."xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.org/dc/terms/identifier | "doi:10.1093/alcalc/ags135"xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/author | "Higuchi S."xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/author | "Kimura M."xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/author | "Maruyama K."xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/author | "Matsushita S."xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/author | "Yokoyama A."xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/author | "Matsui T."xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/author | "Yokoyama T."xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/author | "Mizukami T."xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/name | "Alcohol Alcohol"xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/pages | "146-152"xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/title | "Trends in gastrectomy and ADH1B and ALDH2 genotypes in Japanese alcoholic men and their gene-gastrectomy, gene-gene and gene-age interactions for risk of alcoholism."xsd:string |
http://purl.uniprot.org/citations/23296215 | http://purl.uniprot.org/core/volume | "48"xsd:string |
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http://purl.uniprot.org/uniprot/#_B0LUG2-mappedCitation-23296215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23296215 |
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