| http://purl.uniprot.org/citations/23296467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23296467 | http://www.w3.org/2000/01/rdf-schema#comment | "Colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34) are functional ligands of the CSF1 receptor (CSF1R) and thus are key regulators of the monocyte/macrophage lineage. We discovered that systemic administration of human recombinant CSF1 ameliorates memory deficits in a transgenic mouse model of Alzheimer's disease. CSF1 and IL-34 strongly reduced excitotoxin-induced neuronal cell loss and gliosis in wild-type mice when administered systemically before or up to 6 h after injury. These effects were accompanied by maintenance of cAMP responsive element-binding protein (CREB) signaling in neurons rather than in microglia. Using lineage-tracing experiments, we discovered that a small number of neurons in the hippocampus and cortex express CSF1R under physiological conditions and that kainic acid-induced excitotoxic injury results in a profound increase in neuronal receptor expression. Selective deletion of CSF1R in forebrain neurons in mice exacerbated excitotoxin-induced death and neurodegeneration. We conclude that CSF1 and IL-34 provide powerful neuroprotective and survival signals in brain injury and neurodegeneration involving CSF1R expression on neurons."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20120412"xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Ding Z."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Wyss-Coray T."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Wong G."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "James M.L."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Narasimhan R."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Gambhir S.S."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Pollard J.W."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Relton J."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Getachew R."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Wabl R."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Elwood F."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Britschgi M."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Villeda S."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Fainberg N."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/author | "Alabsi H."xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/pages | "157-172"xsd:string |
| http://purl.uniprot.org/citations/23296467 | http://purl.uniprot.org/core/title | "Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival."xsd:string |