| http://purl.uniprot.org/citations/23300284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23300284 | http://www.w3.org/2000/01/rdf-schema#comment | "Fusion pore formation and expansion, crucial steps for neurotransmitter release and vesicle recycling in soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent vesicle fusion, have not been well studied in vitro due to the lack of a reliable content-mixing fusion assay. Using methods detecting the intervesicular mixing of small and large cargoes at a single-vesicle level, we found that the neuronal SNARE complexes have the capacity to drive membrane hemifusion. However, efficient fusion pore formation and expansion require synaptotagmin 1 and Ca(2+). Real-time measurements show that pore expansion detected by content mixing of large DNA cargoes occurs much slower than initial pore formation that transmits small cargoes. Slow pore expansion perhaps provides a time window for vesicles to escape the full collapse fusion pathway via alternative mechanisms such as kiss-and-run. The results also show that complexin 1 stimulates pore expansion significantly, which could put bias between two pathways of vesicle recycling."xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1218818110"xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/author | "Lai Y."xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/author | "Su Z."xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/author | "Schulten K."xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/author | "Shin Y.K."xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/author | "Diao J."xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/author | "Ha T."xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/author | "Ishitsuka Y."xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/pages | "1333-1338"xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/title | "Fusion pore formation and expansion induced by Ca2+ and synaptotagmin 1."xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23300284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23300284 |
| http://purl.uniprot.org/citations/23300284 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23300284 |
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| http://purl.uniprot.org/uniprot/P21707 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23300284 |