| http://purl.uniprot.org/citations/23300712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23300712 | http://www.w3.org/2000/01/rdf-schema#comment | "The thymic medulla is dedicated for purging the T-cell receptor (TCR) repertoire of self-reactive specificities. Medullary thymic epithelial cells (mTECs) play a pivotal role in this process because they express numerous peripheral tissue-restricted self-antigens. Although it is well known that medulla formation depends on the development of single-positive (SP) thymocytes, the mechanisms underlying this requirement are incompletely understood. We demonstrate here that conventional SP CD4⁺ thymocytes bearing autoreactive TCRs drive a homeostatic process that fine-tunes medullary plasticity in adult mice by governing the expansion and patterning of the medulla. This process exhibits strict dependence on TCR-reactivity with self-antigens expressed by mTECs, as well as engagement of the CD28-CD80/CD86 costimulatory axis. These interactions induce the expression of lymphotoxin α in autoreactive CD4⁺ thymocytes and RANK in mTECs. Lymphotoxin in turn drives mTEC development in synergy with RANKL and CD40L. Our results show that Ag-dependent interactions between autoreactive CD4⁺ thymocytes and mTECs fine-tune homeostasis of the medulla by completing the signaling axes implicated in mTEC expansion and medullary organization."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0052591"xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/author | "Liston A."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/author | "Imhof B.A."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/author | "Irla M."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/author | "Reith W."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/author | "Palmer E."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/author | "Serge A."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/author | "Lantz O."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/author | "Guerri L."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/author | "Guenot J."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/pages | "e52591"xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/title | "Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla."xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/23300712 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23300712 |
| http://purl.uniprot.org/citations/23300712 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23300712 |
| http://purl.uniprot.org/uniprot/#_A0A068BD71-mappedCitation-23300712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23300712 |
| http://purl.uniprot.org/uniprot/#_A0A068BER6-mappedCitation-23300712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23300712 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B5-mappedCitation-23300712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23300712 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHC7-mappedCitation-23300712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23300712 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHL9-mappedCitation-23300712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23300712 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-23300712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23300712 |