| http://purl.uniprot.org/citations/23300798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23300798 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundA single nucleotide polymorphism (SNP) at locus 11q23.3 (rs498872) in the near 5'-UTR of the PHLDB1 gene was recently implicated as a risk factor for gliomas in a genome-wide association study, and this involvement was confirmed in three additional studies.Methodology/principal findingsTo identify possible causal variants in the region, the authors genotyped 15 tagging SNPs in the 200 kb genomic region at 11q23.3 locus in a Chinese Han population-based case-control study with 983 cases and 1024 controls. We found evidence for an association between two independent loci (both the PHLDB1 and the ACRN1 genes) and a predisposition for gliomas. Among the multiple significant SNPs in the PHLDB1 gene region, the rs17749 SNP was the most significant [P = 1.31×10⁻⁶ in a recessive genetic model]. Additionally, two novel SNPs (rs2236661 and rs494560) that were independent of rs17749 were significantly associated with glioma risk in a recessive genetic model [P = 1.31×10⁻⁵ and P = 3.32×10⁻⁵, respectively]. The second novel locus was within the ARCN1 gene, and it was associated with a significantly reduced risk for glioma.Conclusions/significanceOur data strongly support PHLDB1 as a susceptibility gene for glioma, also shedding light on a new potentially candidate gene, ARCN1."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0052864"xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/author | "Lu D."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/author | "Sun B."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/author | "Fan W."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/author | "Mao Y."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/author | "Zhou K."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/pages | "e52864"xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/title | "Fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma."xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/23300798 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23300798 |
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