| http://purl.uniprot.org/citations/23303246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23303246 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNA (miRNA) has an important role as a master regulator of gene expression in immune system and is upregulated during T cell differentiation, however its function is not clear yet. In this study, the contribution of miR-31 in T cell activation was investigated. miR-31 was upregulated during the activation of primary T lymphocytes upon T-cell receptor (TCR) stimulation. Ectopic expression of miR-31 increased the expression of interleukin (IL)-2, while knockdown of endogenous miR-31 decreased the IL-2 expression. To gain more insights into the regulatory mechanism, we performed a bioinformatic analysis and found miR-31 potentially targeted kinase suppressor of ras 2 (KSR2), a repression factor of Ras2 kinase. Using reporter gene and western blotting assays, we confirmed that miR-31 could inhibit KSR2 by directly targeting its 3' untranslated region (UTR). Moreover, miR-31 enhanced nuclear factor of activated T cells (NF-AT) activity in Jurkat T cells, and increased transcription activity of IL-2 promoter in primary T cells. In conclusion, our study demonstrated that miR-31 upregulated IL-2 expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation."xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.org/dc/terms/identifier | "doi:10.1038/gene.2012.58"xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/author | "Xia Q."xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/author | "Xue F."xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/pages | "127-131"xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/title | "miR-31 regulates interleukin 2 and kinase suppressor of ras 2 during T cell activation."xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/23303246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23303246 |
| http://purl.uniprot.org/citations/23303246 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23303246 |
| http://purl.uniprot.org/uniprot/#_Q13169-mappedCitation-23303246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23303246 |
| http://purl.uniprot.org/uniprot/#_Q71V48-mappedCitation-23303246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23303246 |
| http://purl.uniprot.org/uniprot/#_Q6QWN0-mappedCitation-23303246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23303246 |
| http://purl.uniprot.org/uniprot/#_Q16334-mappedCitation-23303246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23303246 |
| http://purl.uniprot.org/uniprot/#_O95974-mappedCitation-23303246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23303246 |
| http://purl.uniprot.org/uniprot/#_Q0GK43-mappedCitation-23303246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23303246 |
| http://purl.uniprot.org/uniprot/#_P60568-mappedCitation-23303246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23303246 |
| http://purl.uniprot.org/uniprot/#_Q309Q7-mappedCitation-23303246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23303246 |
| http://purl.uniprot.org/uniprot/#_Q6NZ91-mappedCitation-23303246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23303246 |