| http://purl.uniprot.org/citations/23305818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23305818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23305818 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila Tribbles (Trbl) encodes the founding member of the Trib family of kinase-like proteins that regulate cell migration, proliferation, growth and homeostasis. Trbl was identified in a misexpression screen in the ovary as an antagonist of border cell migration and acts in part by directing turnover of the C/EBP protein encoded by the gene slow border cells (slbo). The ability of mammalian Trib isoforms to promote C/EBP turnover during tissue differentiation indicates that this function is highly conserved. To better understand the role of Trbl in cell migration, we tested specific Trbl antisera, a trbl null allele and Trbl transgenes bearing site-directed mutations. Trbl is expressed at high levels in the nuclei of follicle cell epithelia and is downregulated in delaminating epithelia as expression of Slbo (C/EBP) is upregulated. This complementary pattern of expression during subsequent cell migration is achieved by negative feedback whereby slbo represses Trbl expression and trbl is necessary and sufficient to promote Slbo protein turnover. A series of point mutations that scan the conserved kinase domain of Trbl reveal that the conserved DLK catalytic loop is required for Trbl-Slbo binding and turnover, as well as for interactions between Trbl subunits, suggesting a mechanism of Trbl function."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2012.12.016"xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2012.12.016"xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Anand G."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Anand G."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Das R."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Das R."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Bouyain S."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Bouyain S."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Dobens L.L."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Dobens L.L."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Pence L."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Pence L."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "LaFerriere H."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "LaFerriere H."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Masoner V."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Masoner V."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Zars T."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/author | "Zars T."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/23305818 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |