| http://purl.uniprot.org/citations/23306155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23306155 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies indicated a role of Derlin-1 in human cancers; however, its expression pattern in non-small cell lung cancer (NSCLC) and the molecular mechanism of Derlin-1 on cancer progression have not been characterized. In the present study, Derlin-1 expression was examined in lung cancer cell lines and human tissues. Derlin-1 overexpression correlated with pTNM stage, lymph node metastasis, and poor overall survival. siRNA knockdown of Derlin-1 impaired anchorage-dependent and anchorage-independent cell growth and invasion in A549 and H1299 cell lines, and its overexpression promoted proliferation and invasion in HBE and LTE cell lines. Derlin-1 depletion decreased matrix metalloproteinase (MMP)-2/9 at both protein and mRNA levels, with decreased MAP kinase/extracellular signal-regulated kinase (ERK)/ERK phosphorylation. Derlin-1 overexpression up-regulated MMP-2/9 expression and ERK phosphorylation, which could be reversed by MAP kinase/ERK kinase inhibitor, PD98059. The effect of Derlin-1 on MMP-2/9 up-regulation was abolished in ERK1/2 siRNA-treated cells. Further analysis showed that Derlin-1 overexpression induced EGFR phosphorylation. EGFR inhibitor blocked Derlin-1-mediated up-regulation of EGFR and ERK phosphorylation. MMP-2/9 and p-ERK up-regulation by Derlin-1 was partly blocked in EGFR-depleted cells with siRNA treatment. Immunoprecipitation confirmed the association between Derlin-1 and EGFR. In summary, our results showed that Derlin-1 is overexpressed in NSCLC and promotes invasion by EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9. Derlin-1 may serve as a therapeutic target for NSCLC."xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajpath.2012.11.019"xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/author | "Fu L."xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/author | "Wang E.D."xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/author | "Wang E.H."xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/author | "Tang Z.P."xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/author | "Li Q.C."xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/author | "Dong Q.Z."xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/pages | "954-964"xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/title | "Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9."xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/23306155 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23306155 |
| http://purl.uniprot.org/citations/23306155 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23306155 |
| http://purl.uniprot.org/uniprot/#_A0A068JD88-mappedCitation-23306155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23306155 |
| http://purl.uniprot.org/uniprot/#_A8K2T7-mappedCitation-23306155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23306155 |
| http://purl.uniprot.org/uniprot/#_A0A068JCC9-mappedCitation-23306155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23306155 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F8-mappedCitation-23306155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23306155 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F6-mappedCitation-23306155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23306155 |
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| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F1-mappedCitation-23306155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23306155 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9G4-mappedCitation-23306155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23306155 |