| http://purl.uniprot.org/citations/23307790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23307790 | http://www.w3.org/2000/01/rdf-schema#comment | "Twelve weeks of high-fat diet feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons. In the current study, we investigated whether diet-induced weight loss could restore NPY/AgRP neuronal responsiveness to ghrelin and whether ghrelin mediates rebound weight gain after calorie-restricted (CR) weight loss. Diet-induced obese (DIO) mice were allocated to one of two dietary interventions until they reached the weight of age-matched lean controls. DIO mice received chow diet ad libitum or chow diet with 40% CR. Chow-fed and high-fat-fed mice served as controls. Both dietary interventions normalized body weight, glucose tolerance, and plasma insulin. We show that diet-induced weight loss with CR increases total plasma ghrelin, restores ghrelin sensitivity, and increases hypothalamic NPY and AgRP mRNA expression. We propose that long-term DIO creates a higher body weight set-point and that weight loss induced by CR, as seen in the high-fat CR group, provokes the brain to protect the new higher set-point. This adaptation to weight loss likely contributes to rebound weight gain by increasing peripheral ghrelin concentrations and restoring the function of ghrelin-responsive neuronal populations in the hypothalamic arcuate nucleus. Indeed, we also show that DIO ghrelin-knockout mice exhibit reduced body weight regain after CR weight loss compared with ghrelin wild-type mice, suggesting ghrelin mediates rebound weight gain after CR weight loss."xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2012-1421"xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/author | "Stark R."xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/author | "Andrews Z.B."xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/author | "Briggs D.I."xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/author | "Lockie S.H."xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/author | "Lemus M.B."xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/pages | "709-717"xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/title | "Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/23307790 | http://purl.uniprot.org/core/volume | "154"xsd:string |
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