| http://purl.uniprot.org/citations/23313255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23313255 | http://www.w3.org/2000/01/rdf-schema#comment | "Head and neck squamous cell carcinoma (HNSCC) is a common type of cancer. Better understanding of molecular aberrations associated with HNSCC might identify new diagnostic and therapeutic strategies for this disease. In this study, we found ubiquitin-specific protease 4 (USP4) was significantly upregulated in HNSCC. USP4 negatively regulates RIP1-mediated NF-κB activation and promotes TNF-α-induced apoptosis in FaDu cells. USP4 directly interacts with receptor-interacting protein 1 (RIP1) and deubiquitinates K63-linked ubiquitination from RIP1. Therefore, our results indicate that USP4 has tumor suppressor roles in HNSCC and suggest USP4 as a potential therapeutic target for HNSCC."xsd:string |
| http://purl.uniprot.org/citations/23313255 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.12.016"xsd:string |
| http://purl.uniprot.org/citations/23313255 | http://purl.uniprot.org/core/author | "Pan X."xsd:string |
| http://purl.uniprot.org/citations/23313255 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/23313255 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/23313255 | http://purl.uniprot.org/core/author | "Zhao W."xsd:string |
| http://purl.uniprot.org/citations/23313255 | http://purl.uniprot.org/core/author | "Hou X."xsd:string |
| http://purl.uniprot.org/citations/23313255 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23313255 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/23313255 | http://purl.uniprot.org/core/pages | "311-316"xsd:string |
| http://purl.uniprot.org/citations/23313255 | http://purl.uniprot.org/core/title | "Ubiquitin-specific protease 4 promotes TNF-alpha-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma."xsd:string |
| http://purl.uniprot.org/citations/23313255 | http://purl.uniprot.org/core/volume | "587"xsd:string |
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