| http://purl.uniprot.org/citations/23319550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23319550 | http://www.w3.org/2000/01/rdf-schema#comment | "Auxin plays a pivotal role in plant development by modulating the activity of SCF ubiquitin ligase complexes. Here, we positionally cloned Arabidopsis (Arabidopsis thaliana) incurvata13 (icu13), a mutation that causes leaf hyponasty and reduces leaf venation pattern complexity and auxin responsiveness. We found that icu13 is a novel recessive allele of AUXIN RESISTANT6 (AXR6), which encodes CULLIN1, an invariable component of the SCF complex. Consistent with a role for auxin in vascular specification, the vascular defects in the icu13 mutant were accompanied by reduced expression of auxin transport and auxin perception markers in provascular cells. This observation is consistent with the expression pattern of AXR6, which we found to be restricted to vascular precursors and hydathodes in wild-type leaf primordia. AXR1, RELATED TO UBIQUITIN1-CONJUGATING ENZYME1, CONSTITUTIVE PHOTOMORPHOGENIC9 SIGNALOSOME5A, and CULLIN-ASSOCIATED NEDD8-DISSOCIATED1 participate in the covalent modification of CULLIN1 by RELATED TO UBIQUITIN. Hypomorphic alleles of these genes also display simple venation patterns, and their double mutant combinations with icu13 exhibited a synergistic, rootless phenotype reminiscent of that caused by loss of function of MONOPTEROS (MP), which forms an auxin-signaling module with BODENLOS (BDL). The phenotypes of double mutant combinations of icu13 with either a gain-of-function allele of BDL or a loss-of-function allele of MP were synergistic. In addition, a BDL:green fluorescent protein fusion protein accumulated in icu13, and BDL loss of function or MP overexpression suppressed the phenotype of icu13. Our results demonstrate that the MP-BDL module is required not only for root specification in embryogenesis and vascular postembryonic development but also for leaf flatness."xsd:string |
| http://purl.uniprot.org/citations/23319550 | http://purl.org/dc/terms/identifier | "doi:10.1104/pp.112.207779"xsd:string |
| http://purl.uniprot.org/citations/23319550 | http://purl.uniprot.org/core/author | "Micol J.L."xsd:string |
| http://purl.uniprot.org/citations/23319550 | http://purl.uniprot.org/core/author | "Ponce M.R."xsd:string |
| http://purl.uniprot.org/citations/23319550 | http://purl.uniprot.org/core/author | "Perez-Perez J.M."xsd:string |
| http://purl.uniprot.org/citations/23319550 | http://purl.uniprot.org/core/author | "Esteve-Bruna D."xsd:string |
| http://purl.uniprot.org/citations/23319550 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23319550 | http://purl.uniprot.org/core/name | "Plant Physiol"xsd:string |
| http://purl.uniprot.org/citations/23319550 | http://purl.uniprot.org/core/pages | "1303-1320"xsd:string |
| http://purl.uniprot.org/citations/23319550 | http://purl.uniprot.org/core/title | "incurvata13, a novel allele of AUXIN RESISTANT6, reveals a specific role for auxin and the SCF complex in Arabidopsis embryogenesis, vascular specification, and leaf flatness."xsd:string |
| http://purl.uniprot.org/citations/23319550 | http://purl.uniprot.org/core/volume | "161"xsd:string |
| http://purl.uniprot.org/citations/23319550 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23319550 |
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| http://purl.uniprot.org/uniprot/#_P43255-mappedCitation-23319550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23319550 |