| http://purl.uniprot.org/citations/23319569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23319569 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone marrow (BM) provides chemoprotection for acute lymphoblastic leukemia (ALL) cells, contributing to lack of efficacy of current therapies. Integrin alpha4 (alpha4) mediates stromal adhesion of normal and malignant B-cell precursors, and according to gene expression analyses from 207 children with minimal residual disease, is highly associated with poorest outcome. We tested whether interference with alpha4-mediated stromal adhesion might be a new ALL treatment. Two models of leukemia were used, one genetic (conditional alpha4 ablation of BCR-ABL1 [p210(+)] leukemia) and one pharmacological (anti-functional alpha4 antibody treatment of primary ALL). Conditional deletion of alpha4 sensitized leukemia cell to nilotinib. Adhesion of primary pre-B ALL cells was alpha4-dependent; alpha4 blockade sensitized primary ALL cells toward chemotherapy. Chemotherapy combined with Natalizumab prolonged survival of NOD/SCID recipients of primary ALL, suggesting adjuvant alpha4 inhibition as a novel strategy for pre-B ALL."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-01-406272"xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Heisterkamp N."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Shimada H."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Park E."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Kim Y.M."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Crooks G.M."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Kang E.S."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Papayannopoulou T."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Geng H."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Koo H.H."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Andrade J."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Hofmann W.K."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Muschen M."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Willman C.L."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Shojaee S."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Hsieh Y.T."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Loh M."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Schaefer P."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Parameswaran R."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Bonig H."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Klemm L."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Gang E.J."xsd:string |
| http://purl.uniprot.org/citations/23319569 | http://purl.uniprot.org/core/author | "Chudziak D."xsd:string |