| http://purl.uniprot.org/citations/23320755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23320755 | http://www.w3.org/2000/01/rdf-schema#comment | "Overexpression of BTBD10 (BTB/POZ domain-containing protein 10) suppresses G93A-superoxide dismutase 1 (SOD1)-induced motor neuron death in a cell-based amyotrophic lateral sclerosis (ALS) model. In the present study, paraffin sections of spinal cords from 13 patients with sporadic ALS and 10 with non-ALS disorders were immunostained using a polyclonal anti-BTBD10 antibody. Reduced BTBD10 expression in the anterior horn cells was more frequent in spinal cords from ALS patients than in cords from patients with non-ALS disorders. We further investigated the relationship between the level of BTBD10 immunoreactivity and the morphology of the Golgi apparatus (GA) and the presence of phosphorylated TAR-DNA-binding protein 43 (pTDP-43). Mirror sections of spinal cords from five sporadic ALS cases were immunostained with antibodies against BTBD10 and trans-Golgi-network (TGN)-46 or pTDP-43. Whereas 89.7-96.5% of the neurons with normal BTBD10 immunoreactivity showed normal GA morphology and no pTDP-43 cytoplasmic aggregates, 86.2-94.3% of the neurons with reduced BTBD10 expression showed GA fragmentation and abnormal pTDP-43 aggregates. These findings suggest that reduced BTBD10 expression is closely linked to the pathogenesis of sporadic ALS."xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.org/dc/terms/identifier | "doi:10.1111/neup.12010"xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/author | "Fujita Y."xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/author | "Ikeda M."xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/author | "Okamoto K."xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/author | "Matsuoka M."xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/author | "Furuta N."xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/author | "Takatama M."xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/author | "Makioka K."xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/name | "Neuropathology"xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/pages | "397-404"xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/title | "Reduced expression of BTBD10 in anterior horn cells with Golgi fragmentation and pTDP-43-positive inclusions in patients with sporadic amyotrophic lateral sclerosis."xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23320755 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23320755 |
| http://purl.uniprot.org/citations/23320755 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23320755 |
| http://purl.uniprot.org/uniprot/#_B7Z2J1-mappedCitation-23320755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23320755 |
| http://purl.uniprot.org/uniprot/#_B7Z503-mappedCitation-23320755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23320755 |
| http://purl.uniprot.org/uniprot/#_A8K8M7-mappedCitation-23320755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23320755 |
| http://purl.uniprot.org/uniprot/#_D3DQW7-mappedCitation-23320755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23320755 |
| http://purl.uniprot.org/uniprot/#_Q7L2U6-mappedCitation-23320755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23320755 |
| http://purl.uniprot.org/uniprot/#_Q6P5W1-mappedCitation-23320755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23320755 |
| http://purl.uniprot.org/uniprot/#_Q9BSF8-mappedCitation-23320755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23320755 |
| http://purl.uniprot.org/uniprot/Q6P5W1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23320755 |