| http://purl.uniprot.org/citations/23325253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23325253 | http://www.w3.org/2000/01/rdf-schema#comment | "Glia exhibit spontaneous and activity-dependent fluctuations in intracellular Ca(2+), yet it is unclear whether glial Ca(2+) oscillations are required during neuronal signaling. Somatic glial Ca(2+) waves are primarily mediated by the release of intracellular Ca(2+) stores, and their relative importance in normal brain physiology has been disputed. Recently, near-membrane microdomain Ca(2+) transients were identified in fine astrocytic processes and found to arise via an intracellular store-independent process. Here, we describe the identification of rapid, near-membrane Ca(2+) oscillations in Drosophila cortex glia of the CNS. In a screen for temperature-sensitive conditional seizure mutants, we identified a glial-specific Na(+)/Ca(2+), K(+) exchanger (zydeco) that is required for microdomain Ca(2+) oscillatory activity. We found that zydeco mutant animals exhibit increased susceptibility to seizures in response to a variety of environmental stimuli, and that zydeco is required acutely in cortex glia to regulate seizure susceptibility. We also found that glial expression of calmodulin is required for stress-induced seizures in zydeco mutants, suggesting a Ca(2+)/calmodulin-dependent glial signaling pathway underlies glial-neuronal communication. These studies demonstrate that microdomain glial Ca(2+) oscillations require NCKX-mediated plasma membrane Ca(2+) flux, and that acute dysregulation of glial Ca(2+) signaling triggers seizures."xsd:string |
| http://purl.uniprot.org/citations/23325253 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3920-12.2013"xsd:string |
| http://purl.uniprot.org/citations/23325253 | http://purl.uniprot.org/core/author | "Littleton J.T."xsd:string |
| http://purl.uniprot.org/citations/23325253 | http://purl.uniprot.org/core/author | "Melom J.E."xsd:string |
| http://purl.uniprot.org/citations/23325253 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23325253 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/23325253 | http://purl.uniprot.org/core/pages | "1169-1178"xsd:string |
| http://purl.uniprot.org/citations/23325253 | http://purl.uniprot.org/core/title | "Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibility."xsd:string |
| http://purl.uniprot.org/citations/23325253 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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