| http://purl.uniprot.org/citations/23325927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23325927 | http://www.w3.org/2000/01/rdf-schema#comment | "Very long-chain fatty acids (VLCFAs), fatty acids with chain-length greater than 20 carbons, possess a wide range of biological functions. However, their roles at the molecular level remain largely unknown. In the present study, we screened for multicopy suppressors that rescued temperature-sensitive growth of VLCFA-limited yeast cells, and we identified the VPS21 gene, encoding a Rab GTPase, as such a suppressor. When the vps21Δ mutation was introduced into a deletion mutant of the SUR4 gene, which encodes a VLCFA elongase, a synthetic growth defect was observed. Endosome-mediated vesicular trafficking pathways, including endocytosis and the carboxypeptidase Y (CPY) pathway, were severely impaired in sur4Δ vps21Δ double mutants, while the AP-3 pathway that bypasses the endosome was unaffected. In addition, the sur4Δ mutant also exhibited a synthetic growth defect when combined with the deletion of VPS3, which encodes a subunit of the class C core vacuole/endosome tethering (CORVET) complex that tethers transport vesicles to the late endosome/multivesicular body (MVB). These results suggest that, of all the intracellular trafficking pathways, requirement of VLCFAs is especially high in the endosomal pathways."xsd:string |
| http://purl.uniprot.org/citations/23325927 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m034678"xsd:string |
| http://purl.uniprot.org/citations/23325927 | http://purl.uniprot.org/core/author | "Obara K."xsd:string |
| http://purl.uniprot.org/citations/23325927 | http://purl.uniprot.org/core/author | "Kihara A."xsd:string |
| http://purl.uniprot.org/citations/23325927 | http://purl.uniprot.org/core/author | "Kojima R."xsd:string |
| http://purl.uniprot.org/citations/23325927 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23325927 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/23325927 | http://purl.uniprot.org/core/pages | "831-842"xsd:string |
| http://purl.uniprot.org/citations/23325927 | http://purl.uniprot.org/core/title | "Effects on vesicular transport pathways at the late endosome in cells with limited very long-chain fatty acids."xsd:string |
| http://purl.uniprot.org/citations/23325927 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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