| http://purl.uniprot.org/citations/23332759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23332759 | http://www.w3.org/2000/01/rdf-schema#comment | "Establishment of oligodendrocyte identity is crucial for subsequent events of myelination in the CNS. Here, we demonstrate that activation of ATP-dependent SWI/SNF chromatin-remodeling enzyme Smarca4/Brg1 at the differentiation onset is necessary and sufficient to initiate and promote oligodendrocyte lineage progression and maturation. Genome-wide multistage studies by ChIP-seq reveal that oligodendrocyte-lineage determination factor Olig2 functions as a prepatterning factor to direct Smarca4/Brg1 to oligodendrocyte-specific enhancers. Recruitment of Smarca4/Brg1 to distinct subsets of myelination regulatory genes is developmentally regulated. Functional analyses of Smarca4/Brg1 and Olig2 co-occupancy relative to chromatin epigenetic marking uncover stage-specific cis-regulatory elements that predict sets of transcriptional regulators controlling oligodendrocyte differentiation. Together, our results demonstrate that regulation of the functional specificity and activity of a Smarca4/Brg1-dependent chromatin-remodeling complex by Olig2, coupled with transcriptionally linked chromatin modifications, is critical to precisely initiate and establish the transcriptional program that promotes oligodendrocyte differentiation and subsequent myelination of the CNS."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.12.006"xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Zhao C."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Kim B."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Mao M."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Chan J.R."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Wu L.M."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/author | "Lu Q.R."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/pages | "248-261"xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/title | "Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://purl.uniprot.org/core/volume | "152"xsd:string |
| http://purl.uniprot.org/citations/23332759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23332759 |
| http://purl.uniprot.org/citations/23332759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23332759 |
| http://purl.uniprot.org/uniprot/#_A0A087WRZ9-mappedCitation-23332759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23332759 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUD9-mappedCitation-23332759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23332759 |