| http://purl.uniprot.org/citations/23332762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23332762 | http://www.w3.org/2000/01/rdf-schema#comment | "The IκB kinase complex (IKK) is a key regulator of immune responses, inflammation, cell survival, and tumorigenesis. The prosurvival function of IKK centers on activation of the transcription factor NF-κB, whose target gene products inhibit caspases and prevent prolonged JNK activation. Here, we report that inactivation of the BH3-only protein BAD by IKK independently of NF-κB activation suppresses TNFα-induced apoptosis. TNFα-treated Ikkβ(-/-) mouse embryonic fibroblasts (MEFs) undergo apoptosis significantly faster than MEFs deficient in both RelA and cRel due to lack of inhibition of BAD by IKK. IKK phosphorylates BAD at serine-26 (Ser26) and primes it for inactivation. Elimination of Ser26 phosphorylation promotes BAD proapoptotic activity, thereby accelerating TNFα-induced apoptosis in cultured cells and increasing mortality in animals. Our results reveal that IKK inhibits TNFα-induced apoptosis through two distinct but cooperative mechanisms: activation of the survival factor NF-κB and inactivation of the proapoptotic BH3-only BAD protein."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.12.021"xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/author | "Lin Y."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/author | "Xiang J."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/author | "Lin A."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/author | "Danial N.N."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/pages | "304-315"xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/title | "Inactivation of BAD by IKK inhibits TNFalpha-induced apoptosis independently of NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://purl.uniprot.org/core/volume | "152"xsd:string |
| http://purl.uniprot.org/citations/23332762 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23332762 |
| http://purl.uniprot.org/citations/23332762 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23332762 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0T4-mappedCitation-23332762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23332762 |
| http://purl.uniprot.org/uniprot/#_Q0X0E6-mappedCitation-23332762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23332762 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-23332762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23332762 |
| http://purl.uniprot.org/uniprot/#_A4L9Q2-mappedCitation-23332762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23332762 |
| http://purl.uniprot.org/uniprot/#_A0A494B901-mappedCitation-23332762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23332762 |