| http://purl.uniprot.org/citations/23333275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23333275 | http://www.w3.org/2000/01/rdf-schema#comment | "TDP-43 proteinopathy is strongly implicated in the pathogenesis of amyotrophic lateral sclerosis and related neurodegenerative disorders. Whether TDP-43 neurotoxicity is caused by a novel toxic gain-of-function mechanism of the aggregates or by a loss of its normal function is unknown. We increased and decreased expression of TDP-43 (dTDP-43) in Drosophila. Although upregulation of dTDP-43 induced neuronal ubiquitin and dTDP-43-positive inclusions, both up- and downregulated dTDP-43 resulted in selective apoptosis of bursicon neurons and highly similar transcriptome alterations at the pupal-adult transition. Gene network analysis and genetic validation showed that both up- and downregulated dTDP-43 directly and dramatically increased the expression of the neuronal microtubule-associated protein Map205, resulting in cytoplasmic accumulations of the ecdysteroid receptor (EcR) and a failure to switch EcR-dependent gene programs from a pupal to adult pattern. We propose that dTDP-43 neurotoxicity is caused by a loss of its normal function."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2012.12.014"xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Adachi Y."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Van Broeckhoven C."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Kleinberger G."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Chapuis J."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Dermaut B."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Dourlen P."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Lambert J.C."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Callaerts P."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Aerts S."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Hirth F."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Gistelinck M."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Naval-Sanchez M."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Diaper D."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/author | "Vanden Broeck L."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/pages | "160-172"xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/title | "TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/23333275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23333275 |
| http://purl.uniprot.org/citations/23333275 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23333275 |
| http://purl.uniprot.org/uniprot/Q8SXP8#attribution-57F3B3FA7799FCFBC64B638351A03E03 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23333275 |