| http://purl.uniprot.org/citations/23333597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23333597 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study we report that expression of glioma pathogenesis-related protein 1 (GLIPR1) regulated numerous apoptotic, cell cycle, and spindle/centrosome assembly-related genes, including AURKA and TPX2, and induced apoptosis and/or mitotic catastrophe (MC) in prostate cancer (PCa) cells, including p53-mutated/deleted, androgen-insensitive metastatic PCa cells. Mechanistically, GLIPR1 interacts with heat shock cognate protein 70 (Hsc70); this interaction is associated with SP1 and c-Myb destabilization and suppression of SP1- and c-Myb-mediated AURKA and TPX2 transcription. Inhibition of AURKA and TPX2 using siRNA mimicked enforced GLIPR1 expression in the induction of apoptosis and MC. Recombinant GLIPR1-ΔTM protein inhibited AURKA and TPX2 expression, induced apoptosis and MC, and suppressed orthotopic xenograft tumor growth. Our results define a novel GLIPR1-regulated signaling pathway that controls apoptosis and/or mitotic catastrophe in PCa cells and establishes the potential of this pathway for targeted therapies."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molonc.2012.12.005"xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Kim S.M."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Hirayama T."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Yang G."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Ren C."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Hawke D."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Ittmann M.M."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Goltsov A.A."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Thompson T.C."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Troncoso P."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/author | "Tanimoto R."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/name | "Mol Oncol"xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/pages | "484-496"xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/title | "Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2."xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/23333597 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23333597 |
| http://purl.uniprot.org/citations/23333597 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23333597 |
| http://purl.uniprot.org/uniprot/#_P11142-mappedCitation-23333597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23333597 |