| http://purl.uniprot.org/citations/23333871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23333871 | http://www.w3.org/2000/01/rdf-schema#comment | "The Nobel prize has been awarded for the discovery of ubiquitin as a transferable signal for the degradation of proteins by the 26S proteasome. While isopeptide linkage of a protein with a single ubiquitin does not serve as a degradation signal for the proteasome, poly-ubiquitylation via several different lysine residues within ubiquitin leads to efficient proteasomal degradation. Ubiquitin-like modifiers have not been shown to directly mediate proteasomal degradation except for the cytokine inducible modifier HLA-F adjacent transcript 10 (FAT10), which consists of two ubiquitin-like domains. FAT10 ends with a free diglycine motif at its C-terminus which is required for isopeptide linkage to hundreds of different substrates. In contrast to ubiquitin, a single FAT10 suffices to bind to the 26S proteasome and to efficiently mediate proteasomal degradation in a ubiquitin-independent manner. Here we review the data on ubiquitin-independent degradation by FAT10, on how FAT10 is conjugated to its substrates, how FAT10 binds to the 26S proteasome, and how the ubiquitin-like (UBL)-ubiquitin-associated (UBA) protein NUB1L accelerates FAT10 mediated proteolysis. Finally, with a glimpse on recently identified substrates, we will discuss the currently emerging knowledge about the biological functions of FAT10. This article is part of a Special Issue entitled: Ubiquitin-Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf."xsd:string |
| http://purl.uniprot.org/citations/23333871 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2013.01.009"xsd:string |
| http://purl.uniprot.org/citations/23333871 | http://purl.uniprot.org/core/author | "Aichem A."xsd:string |
| http://purl.uniprot.org/citations/23333871 | http://purl.uniprot.org/core/author | "Groettrup M."xsd:string |
| http://purl.uniprot.org/citations/23333871 | http://purl.uniprot.org/core/author | "Schmidtke G."xsd:string |
| http://purl.uniprot.org/citations/23333871 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23333871 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/23333871 | http://purl.uniprot.org/core/pages | "97-102"xsd:string |
| http://purl.uniprot.org/citations/23333871 | http://purl.uniprot.org/core/title | "FAT10ylation as a signal for proteasomal degradation."xsd:string |
| http://purl.uniprot.org/citations/23333871 | http://purl.uniprot.org/core/volume | "1843"xsd:string |
| http://purl.uniprot.org/citations/23333871 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23333871 |
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| http://purl.uniprot.org/uniprot/#_Q15008-mappedCitation-23333871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23333871 |
| http://purl.uniprot.org/uniprot/#_A5LHX3-mappedCitation-23333871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23333871 |
| http://purl.uniprot.org/uniprot/#_O15205-mappedCitation-23333871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23333871 |
| http://purl.uniprot.org/uniprot/#_O43242-mappedCitation-23333871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23333871 |
| http://purl.uniprot.org/uniprot/#_P40306-mappedCitation-23333871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23333871 |
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| http://purl.uniprot.org/uniprot/#_O00231-mappedCitation-23333871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23333871 |
| http://purl.uniprot.org/uniprot/#_O00232-mappedCitation-23333871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23333871 |
| http://purl.uniprot.org/uniprot/#_O00233-mappedCitation-23333871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23333871 |
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| http://purl.uniprot.org/uniprot/#_P28065-mappedCitation-23333871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23333871 |