| http://purl.uniprot.org/citations/23334328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23334328 | http://www.w3.org/2000/01/rdf-schema#comment | "Little is known about chromatin mechanisms that regulate tumor-initiating cells that are proposed to be responsible for tumor recurrence and relapse. We have previously shown that Pygopus 2 (Pygo2), a chromatin effector and context-dependent Wnt signaling coactivator, regulates mammary gland development by expanding epithelial stem/progenitor cells. However, the role of Pygo2 in mammary tumorigenesis in vivo remains to be addressed. In this study, we show that epithelia-specific ablation of Pygo2 in MMTV-Wnt1 transgenic mice results in delayed mammary ductal elongation, but the hyperbranching phenotype, aberrant accumulation of stem/progenitor-like cells, and canonical Wnt signaling output are largely unaffected. Chronic loss of Pygo2 significantly delays mammary tumor onset in MMTV-Wnt1 females, whereas acute deletion of Pygo2 in MMTV-Wnt1 tumor cells leads to a significant decrease in their tumor-initiating capability upon transplantation. Finally, we provide evidence supporting a role for Pygo2 in modulating the lineage potential of MMTV-Wnt1 tumor initiating cells. Collectively, our results suggest that Pygo2 acts at a step downstream of mammary stem cell accumulation to facilitate transformation, and that it regulates the tumor initiating capacity and lineage preference of the already transformed mammary cells, in MMTV-Wnt1 mice. These findings offer valuable insights into our understanding of the molecular basis of heterogeneity within breast tumors."xsd:string |
| http://purl.uniprot.org/citations/23334328 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2012.620"xsd:string |
| http://purl.uniprot.org/citations/23334328 | http://purl.uniprot.org/core/author | "Dai X."xsd:string |
| http://purl.uniprot.org/citations/23334328 | http://purl.uniprot.org/core/author | "Watanabe K."xsd:string |
| http://purl.uniprot.org/citations/23334328 | http://purl.uniprot.org/core/author | "Fallahi M."xsd:string |
| http://purl.uniprot.org/citations/23334328 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23334328 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/23334328 | http://purl.uniprot.org/core/pages | "632-642"xsd:string |
| http://purl.uniprot.org/citations/23334328 | http://purl.uniprot.org/core/title | "Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice."xsd:string |
| http://purl.uniprot.org/citations/23334328 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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