| http://purl.uniprot.org/citations/23335597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23335597 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased levels of nicotinamide/nicotinic acid mononucleotide adenylyltransferase (NMNAT) act as a powerful suppressor of Wallerian degeneration and ataxin- and tau-induced neurodegeneration in flies and mice. However, the nature of the suppression mechanism/s remains controversial. Here, we show that in yeast models of proteinopathies, overexpression of the NMNAT yeast homologs, NMA1 and NMA2, suppresses polyglutamine (PolyQ) and α-synuclein-induced cytotoxicities. Unexpectedly, overexpression of other genes in the salvage pathway for NAD(+) biosynthesis, including QNS1, NPT1 and PNC1 also protected against proteotoxicity. Our data revealed that in all cases, this mechanism involves extensive clearance of the non-native protein. Importantly, we demonstrate that suppression by NMA1 does not require the presence of a functional salvage pathway for NAD(+) biosynthesis, SIR2 or an active mitochondrial oxidative phosphorylation (OXPHOS) system. Our results imply the existence of histone deacetylase- and OXPHOS-independent crosstalk between the proteins in the salvage pathway for NAD(+) biosynthesis and the proteasome that can be manipulated to achieve cellular protection against proteotoxic stress."xsd:string |
| http://purl.uniprot.org/citations/23335597 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddt016"xsd:string |
| http://purl.uniprot.org/citations/23335597 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/23335597 | http://purl.uniprot.org/core/author | "Barrientos A."xsd:string |
| http://purl.uniprot.org/citations/23335597 | http://purl.uniprot.org/core/author | "Ocampo A."xsd:string |
| http://purl.uniprot.org/citations/23335597 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23335597 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/23335597 | http://purl.uniprot.org/core/pages | "1699-1708"xsd:string |
| http://purl.uniprot.org/citations/23335597 | http://purl.uniprot.org/core/title | "NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins."xsd:string |
| http://purl.uniprot.org/citations/23335597 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/23335597 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23335597 |
| http://purl.uniprot.org/citations/23335597 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23335597 |
| http://purl.uniprot.org/uniprot/#_A0A6A5PR81-mappedCitation-23335597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/#_A0A6A5PWV9-mappedCitation-23335597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/#_P39683-mappedCitation-23335597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/#_Q06178-mappedCitation-23335597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/#_P38795-mappedCitation-23335597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/#_P53184-mappedCitation-23335597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/#_P53204-mappedCitation-23335597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/P53184 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/P38795 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/P39683 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/A0A6A5PWV9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23335597 |
| http://purl.uniprot.org/uniprot/P53204 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23335597 |