| http://purl.uniprot.org/citations/23337876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23337876 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy is a self-degrading process that is triggered by diverse stimuli including ionizing radiation. In this study we show novel phenomena in which transfection of miR-199a-5p mimic significantly suppresses IR-induced autophagy in MCF7 cells, and up-regulates basal and IR-induced autophagy in MDA-MB-231 breast cancer cells. We also identify DRAM1 and Beclin1 as novel target genes for miR-199a-5p. Overexpression of miR-199a-5p inhibits DRAM1 and Beclin1 expression in MCF7 cells, while it enhances expression of these genes in MDA-MB-231 cells. Furthermore, we show that miR-199a-5p sensitizes MDA-MB-231 cells to irradiation. Therefore, our data identify miR-199a-5p as a novel and unique regulator of autophagy, which plays an important role in cancer biology and cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.12.027"xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/author | "Jia J."xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/author | "Liang B."xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/author | "Yi H."xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/author | "Liang N."xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/author | "Ju G."xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/pages | "436-443"xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/title | "Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://purl.uniprot.org/core/volume | "587"xsd:string |
| http://purl.uniprot.org/citations/23337876 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23337876 |
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