| http://purl.uniprot.org/citations/23341075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23341075 | http://www.w3.org/2000/01/rdf-schema#comment | "Reading disabilities (RD) have a significant genetic basis and have shown linkage to multiple regions including chromosome 15q. Dyslexia susceptibility 1 candidate gene 1 (DYX1C1) on chromosome 15q21 was originally proposed as a candidate gene with two potentially functional polymorphisms at the -3G/A and 1249G/T positions showing association with RD. However, subsequent studies have yielded mixed results. We performed a literature review and meta-analysis of the -3G/A and 1249G/T polymorphisms, including new unpublished data from two family-based samples. Ten markers in DYX1C1 were genotyped in the two independently ascertained samples. Single marker and -3G/A:1249G/T haplotype analyses were performed for RD in both samples, and quantitative trait analyses using standardized reading-related measures was performed in one of the samples. For the meta-analysis, we used a random-effects model to summarize studies that tested for association between -3G/A or 1249G/T and RD. No significant association was found between the DYX1C1 SNPs and RD or any of the reading-related measures tested after correction for the number of tests performed. The previously reported risk haplotype (-3A:1249T) was not biased in transmission. A total of 9 and 10 study samples were included in the meta-analysis of the -3G/A and 1249G/T polymorphisms, respectively. Neither polymorphism reached statistical significance, but the heterogeneity for the 1249G/T polymorphism was high. The results of this study do not provide evidence for association between the putatively functional SNPs -3G/A and 1249G/T and RD."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.org/dc/terms/identifier | "doi:10.1002/ajmg.b.32123"xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Gomez L."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Tran C."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Barr C.L."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Field L.L."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Gagnon F."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Cate-Carter T.D."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Lovett M.W."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Wigg K.G."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Kerr E.N."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/author | "Kaplan B.J."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/name | "Am J Med Genet B Neuropsychiatr Genet"xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/pages | "146-156"xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/title | "A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1."xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://purl.uniprot.org/core/volume | "162B"xsd:string |
| http://purl.uniprot.org/citations/23341075 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23341075 |
| http://purl.uniprot.org/citations/23341075 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23341075 |
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| http://purl.uniprot.org/uniprot/#_A0A0S2Z5Y0-mappedCitation-23341075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23341075 |
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| http://purl.uniprot.org/uniprot/#_B4DY92-mappedCitation-23341075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23341075 |