| http://purl.uniprot.org/citations/23341629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23341629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23341629 | http://www.w3.org/2000/01/rdf-schema#comment | "The microRNA-183/96/182 cluster is highly expressed in the retina and other sensory organs. To uncover its in vivo functions in the retina, we generated a knockout mouse model, designated "miR-183C(GT/GT)," using a gene-trap embryonic stem cell clone. We provide evidence that inactivation of the cluster results in early-onset and progressive synaptic defects of the photoreceptors, leading to abnormalities of scotopic and photopic electroretinograms with decreased b-wave amplitude as the primary defect and progressive retinal degeneration. In addition, inactivation of the miR-183/96/182 cluster resulted in global changes in retinal gene expression, with enrichment of genes important for synaptogenesis, synaptic transmission, photoreceptor morphogenesis, and phototransduction, suggesting that the miR-183/96/182 cluster plays important roles in postnatal functional differentiation and synaptic connectivity of photoreceptors."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1212655110"xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1212655110"xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Valle D."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Valle D."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Cowan C."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Cowan C."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Zack D.J."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Zack D.J."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Kovacs B."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Kovacs B."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Corbett N.J."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Corbett N.J."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Nicholson D.A."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Nicholson D.A."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Haldin C.E."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Haldin C.E."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Witmer P.D."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Witmer P.D."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Larsen P.E."xsd:string |
| http://purl.uniprot.org/citations/23341629 | http://purl.uniprot.org/core/author | "Larsen P.E."xsd:string |