| http://purl.uniprot.org/citations/23345520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23345520 | http://www.w3.org/2000/01/rdf-schema#comment | "Far-upstream element-binding protein 2 (FBP2) is an internal ribosomal entry site (IRES) trans-acting factor (ITAF) that negatively regulates enterovirus 71 (EV71) translation. This study shows that EV71 infection cleaved FBP2. Live EV71 and the EV71 replicon (but not UV-inactivated virus particles) induced FBP2 cleavage, suggesting that viral replication results in FBP2 cleavage. The results also showed that virus-induced proteasome, autophagy, and caspase activity co-contribute to EV71-induced FBP2 cleavage. Using FLAG-fused FBP2, we mapped the potential cleavage fragments of FBP2 in infected cells. We also found that FBP2 altered its function when its carboxyl terminus was cleaved. This study presents a mechanism for virus-induced cellular events to cleave a negative regulator for viral IRES-driven translation."xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.02278-12"xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/author | "Lin J.Y."xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/author | "Chen L.L."xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/author | "Shih S.R."xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/author | "Weng K.F."xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/author | "Horng J.T."xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/author | "Kung Y.A."xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/pages | "3828-3838"xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/title | "Enterovirus 71 infection cleaves a negative regulator for viral internal ribosomal entry site-driven translation."xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/23345520 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23345520 |
| http://purl.uniprot.org/citations/23345520 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23345520 |
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