| http://purl.uniprot.org/citations/23349877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23349877 | http://www.w3.org/2000/01/rdf-schema#comment | "Genotoxic stress and RAS induce the expression of CD155, a ligand for the immune receptors DNAM-1, CD96 and TIGIT. Here we show that antigen-presenting cells upregulate CD155 expression in response to Toll-like receptor activation. Induction of CD155 by Toll-like receptors depended on MYD88, TRIF and NF-κB. In addition, IRF3, but not IRF7, modulated CD155 upregulation in response to TLR3 signals. Immunization of CD155-deficient mice with OVA and the TLR9 agonist CpG resulted in increased OVA-specific IgG2a/c titers when compared to wild type mice. Splenocytes of immunized CD155-deficient mice secreted lower levels of IL-4 and fewer IL-4 and GATA-3 expressing CD4(+) T cells were present in the spleen of Cd155(-/-) mice. Our data suggest that CD155 regulates T(h)2 differentiation. Targeting of CD155 in immunization protocols using peptides may represent a promising new approach to boost protective humoral immunity in viral vaccines."xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0054406"xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/author | "Miyoshi J."xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/author | "Biswas S.K."xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/author | "Gasser S."xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/author | "Wong J.S."xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/author | "Kamran N."xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/pages | "e54406"xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/title | "Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells."xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23349877 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23349877 |
| http://purl.uniprot.org/citations/23349877 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23349877 |
| http://purl.uniprot.org/uniprot/#_A0A140LHC2-mappedCitation-23349877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23349877 |
| http://purl.uniprot.org/uniprot/#_P70671-mappedCitation-23349877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23349877 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-23349877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23349877 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-23349877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23349877 |
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| http://purl.uniprot.org/uniprot/#_A0A140LHT8-mappedCitation-23349877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23349877 |
| http://purl.uniprot.org/uniprot/#_A0A140LI96-mappedCitation-23349877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23349877 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRH7-mappedCitation-23349877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23349877 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GTA2-mappedCitation-23349877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23349877 |