| http://purl.uniprot.org/citations/23351194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23351194 | http://www.w3.org/2000/01/rdf-schema#comment | "CD81 is a major receptor for Hepatitis C Virus (HCV). It belongs to the tetraspanin family whose members form dynamic clusters with numerous partner proteins and with one another, forming tetraspanin-enriched areas in the plasma membrane. In our study, we combined single-molecule microscopy and biochemistry experiments to investigate the clustering and membrane behaviour of CD81 in the context of cells expressing EWI-2wint, a natural inhibitor of HCV entry. Interestingly, we found that EWI-2wint reduces the global diffusion of CD81 molecules due to a decrease of the diffusion rate of mobile CD81 molecules and an increase in the proportion of confined molecules. Indeed, we demonstrated that EWI-2wint promotes CD81 clustering and confinement in CD81-enriched areas. In addition, we showed that EWI-2wint influences the colocalization of CD81 with Claudin-1 - a co-receptor required for HCV entry. Together, our results indicate that a change in membrane partitioning of CD81 occurs in the presence of EWI-2wint. This study gives new insights on the mechanism by which HCV enters into its target cells, namely by exploiting the dynamic properties of CD81."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.org/dc/terms/identifier | "doi:10.1111/cmi.12112"xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Cocquerel L."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Dubuisson J."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Montpellier C."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Milhiet P.E."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Rubinstein E."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Werkmeister E."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Tews B.A."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Popescu C.I."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Baumert T.F."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Couturier C."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Kaestner L."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Rassam P."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/author | "Potel J."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/name | "Cell Microbiol"xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/pages | "1234-1252"xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/title | "EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry."xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/23351194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23351194 |
| http://purl.uniprot.org/citations/23351194 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23351194 |
| http://purl.uniprot.org/uniprot/#_E9PJK1-mappedCitation-23351194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23351194 |
| http://purl.uniprot.org/uniprot/#_P60033-mappedCitation-23351194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23351194 |