| http://purl.uniprot.org/citations/23352666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23352666 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe the use of a unique DNA-modification-dependent restriction endonuclease AbaSI coupled with sequencing (Aba-seq) to map high-resolution hydroxymethylome of mouse E14 embryonic stem cells. The specificity of AbaSI enables sensitive detection of 5-hydroxymethylcytosine (5hmC) at low-occupancy regions. Bioinformatic analysis suggests 5hmCs in genic regions closely follow the 5mC distribution. 5hmC is generally depleted in CpG islands and only enriched in a small set of repetitive elements. A regularly spaced and oscillating 5hmC pattern was observed at the binding sites of CTCF. 5hmC is enriched at the poised enhancers with the monomethylated histone H3 lysine 4 (H3K4me1) marks, but not at the active enhancers with the acetylated histone H3 lysine 27 (H3K27Ac) marks. Non-CG hydroxymethylation appears to be prevalent in the mitochondrial genome. We propose that some amounts of transiently stable 5hmCs may indicate a poised epigenetic state or demethylation intermediate, whereas others may suggest a locally accessible chromosomal environment for the TET enzymatic apparatus."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2013.01.001"xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Cheng X."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Sun D."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Guan S."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Pradhan S."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Terragni J."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Borgaro J.G."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/author | "Jolyon T."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/pages | "567-576"xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/title | "High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells."xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/23352666 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23352666 |
| http://purl.uniprot.org/citations/23352666 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23352666 |
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| http://purl.uniprot.org/uniprot/B0VN39 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23352666 |