| http://purl.uniprot.org/citations/23352961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23352961 | http://www.w3.org/2000/01/rdf-schema#comment | "Natural killer and T cell-mediated cytotoxicity is important for the elimination of viruses and transformed cells. The granule lytic pathway utilizes perforin and granzymes to induce cell death, while receptor-mediated lytic pathways rely on molecules such as FasL. Pro-apoptotic activities of Granzyme B (GrB) and Fas are well-established, and many of their cellular targets have been identified. However, humans express additional related granzymes - GrA, GrM, GrK, and GrH. Neither the cytotoxic potential of GrH, nor the mechanism by which GrH may induce target cell death is currently understood. We proposed that GrH would have pro-apoptotic activity that would be distinct from that of GrB and FasL, which could be relevant when Fas/FasL or GrB activity or death pathways were impaired. Our results, using a purified recombinant form of GrH, revealed that GrH induced cell death via a Bcl-2-sensitive mitochondrial pathway without direct processing of Bid. Additionally, neither the apoptosome nor caspase-3 was essential to the induction of GrH-mediated cell death. However, GrH did directly process DFF45, potentially leading to DNA damage. Our findings support the idea that multiple, non-redundant death pathways may be initiated by cytotoxic cells to counteract various immune evasion strategies."xsd:string |
| http://purl.uniprot.org/citations/23352961 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2012.12.020"xsd:string |
| http://purl.uniprot.org/citations/23352961 | http://purl.uniprot.org/core/author | "Bleackley R.C."xsd:string |
| http://purl.uniprot.org/citations/23352961 | http://purl.uniprot.org/core/author | "Kane K.P."xsd:string |
| http://purl.uniprot.org/citations/23352961 | http://purl.uniprot.org/core/author | "Ewen C.L."xsd:string |
| http://purl.uniprot.org/citations/23352961 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23352961 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/23352961 | http://purl.uniprot.org/core/pages | "309-318"xsd:string |
| http://purl.uniprot.org/citations/23352961 | http://purl.uniprot.org/core/title | "Granzyme H induces cell death primarily via a Bcl-2-sensitive mitochondrial cell death pathway that does not require direct Bid activation."xsd:string |
| http://purl.uniprot.org/citations/23352961 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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