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http://purl.uniprot.org/citations/23353684 | http://www.w3.org/2000/01/rdf-schema#comment | "α(2)-Macroglobulin (α(2)M) is an extracellular chaperone that inhibits amorphous and fibrillar protein aggregation. The reaction of α(2)M with proteases results in an 'activated' conformation, where the proteases become covalently-linked within the interior of a cage-like structure formed by α(2)M. This study investigates, the effect of activation on the ability of α(2)M to inhibit amyloid formation by Aβ(1-42) and I59T human lysozyme and shows that protease-activated α(2)M can act via two distinct mechanisms: (i) by trapping proteases that remain able to degrade polypeptide chains and (ii) by a chaperone action that prevents misfolded clients from continuing along the amyloid forming pathway."xsd:string |
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http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Dobson C.M."xsd:string |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Wilson M.R."xsd:string |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Yerbury J.J."xsd:string |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Ecroyd H."xsd:string |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Kumita J.R."xsd:string |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Wyatt A.R."xsd:string |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/author | "Constantinescu P."xsd:string |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/pages | "398-403"xsd:string |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/title | "Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms."xsd:string |
http://purl.uniprot.org/citations/23353684 | http://purl.uniprot.org/core/volume | "587"xsd:string |
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