| http://purl.uniprot.org/citations/23353780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23353780 | http://www.w3.org/2000/01/rdf-schema#comment | "Pediatric leukemia survival rates have improved dramatically over the past decades. However, current treatment protocols are still largely ineffective in cases of relapsed leukemia and are associated with a significant rate of chronic health conditions. Thus, there is a continued need for new therapeutic options. Here, we show that mer receptor tyrosine kinase (MerTK) was abnormally expressed in approximately one half of pediatric T-cell leukemia patient samples and T-cell acute lymphoblastic leukemia (T-ALL) cell lines. Stimulation of MerTK by the ligand Gas6 led to activation of the prosurvival proteins Erk 1/2 and Stat5, and MerTK-dependent activation of the STAT pathway in leukemia represents a novel finding. Furthermore, inhibition of MerTK expression increased the sensitivity of T-ALL cells to treatment with chemotherapeutic agents and decreased the oncogenic potential of the Jurkat T-ALL cell line in a methylcellulose colony-forming assay. Lastly, inhibition of MerTK expression significantly increased median survival in a xenograft mouse model of leukemia (30.5 days vs 60 days, P<0.0001). These results suggest that inhibition of MerTK is a promising therapeutic strategy for the treatment of leukemia and may allow for dose reduction of currently used chemotherapeutics resulting in decreased rates of therapy-associated toxicities."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.org/dc/terms/identifier | "doi:10.1038/bcj.2012.46"xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "Gao D."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "Liang X."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "Sather S."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "Graham D.K."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "Schlegel J."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "Deryckere D."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "Migdall-Wilson J."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "Christoph S."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "Brandao L.N."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "McGranahan A."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/author | "Winges A."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/name | "Blood Cancer J"xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/pages | "e101"xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/title | "Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia."xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/23353780 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23353780 |
| http://purl.uniprot.org/citations/23353780 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23353780 |
| http://purl.uniprot.org/uniprot/Q12866#attribution-74EE95757B119F9EFC5764C677EBA3EF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23353780 |
| http://purl.uniprot.org/uniprot/#_P27361-mappedCitation-23353780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23353780 |
| http://purl.uniprot.org/uniprot/#_P42229-mappedCitation-23353780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23353780 |
| http://purl.uniprot.org/uniprot/P42229 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23353780 |