| http://purl.uniprot.org/citations/23353830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23353830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23353830 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear pore complex is the sole mediator of bidirectional transport between the nucleus and cytoplasm. Nup358 is a metazoan-specific nucleoporin that localizes to the cytoplasmic filaments and provides several binding sites for the mobile nucleocytoplasmic transport machinery. Here we present the crystal structure of the C-terminal domain (CTD) of Nup358 at 1.75Å resolution. The structure reveals that the CTD adopts a cyclophilin-like fold with a non-canonical active-site configuration. We determined biochemically that the CTD possesses weak peptidyl-prolyl isomerase activity and show that the active-site cavity mediates a weak association with the human immunodeficiency virus-1 capsid protein, supporting its role in viral infection. Overall, the surface is evolutionarily conserved, suggesting that the CTD serves as a protein-protein interaction platform. However, we demonstrate that the CTD is dispensable for nuclear envelope localization of Nup358, suggesting that the CTD does not interact with other nucleoporins."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2013.01.021"xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2013.01.021"xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/author | "Hoelz A."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/author | "Hoelz A."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/author | "Zimmermann S."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/author | "Zimmermann S."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/author | "Lin D.H."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/author | "Lin D.H."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/author | "Stuwe T."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/author | "Stuwe T."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/author | "Stuwe E."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/author | "Stuwe E."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/pages | "1318-1329"xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/pages | "1318-1329"xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/title | "Structural and functional analysis of the C-terminal domain of Nup358/RanBP2."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/title | "Structural and functional analysis of the C-terminal domain of Nup358/RanBP2."xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/volume | "425"xsd:string |
| http://purl.uniprot.org/citations/23353830 | http://purl.uniprot.org/core/volume | "425"xsd:string |