| http://purl.uniprot.org/citations/23362875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23362875 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent case reports suggest that treatment with glucagon-like peptide-1 (GLP-1) agonists results in clinical improvement of psoriasis. The purpose of this study was to determine whether GLP-1 receptors (GLP-1Rs) are found in the skin of healthy volunteers and psoriasis patients and if so, whether GLP-1Rs are located on keratinocytes or immune cells. Three mm-punch skin biopsies were taken for gene expression analysis from six healthy volunteers and from affected and unaffected skin of six psoriasis patients. In addition, a blood sample was obtained from all participants. Cultured human keratinocytes were either untreated or incubated with tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) or a combination of TNF-α and IFN-γ for 48 h. Total RNA was extracted from all the samples, reversely transcribed and analysed for the expression of GLP-1R using real-time PCR. Gene expression analysis showed expression of GLP-1Rs in five of six skin biopsies from psoriasis plaques, in one of six biopsies from unaffected psoriatic skin and in one of six biopsies from healthy skin. GLP-1R expression was found in the blood of both healthy volunteers and psoriasis patients. No GLP-1R expression was found in either stimulated or unstimulated cultured human keratinocytes. Our results show increased presence of GLP-1Rs in psoriasis plaques and that this most likely is due to infiltration with immune cells. This offers a possible explanation for the positive effect of treatment with GLP-1R agonists in patients with psoriasis."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.org/dc/terms/identifier | "doi:10.1111/exd.12081"xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/author | "Pedersen J."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/author | "Poulsen S.S."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/author | "Holst J.J."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/author | "Skov L."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/author | "Knop F.K."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/author | "Vilsboll T."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/author | "Faurschou A."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/author | "Thyssen J.P."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/author | "Zachariae C."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/author | "Gyldenlove M."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/name | "Exp Dermatol"xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/pages | "150-152"xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/title | "Increased expression of glucagon-like peptide-1 receptors in psoriasis plaques."xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/23362875 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23362875 |
| http://purl.uniprot.org/citations/23362875 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23362875 |
| http://purl.uniprot.org/uniprot/#_A0A142FHB8-mappedCitation-23362875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23362875 |
| http://purl.uniprot.org/uniprot/#_P43220-mappedCitation-23362875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23362875 |
| http://purl.uniprot.org/uniprot/P43220 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23362875 |
| http://purl.uniprot.org/uniprot/A0A142FHB8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23362875 |