| http://purl.uniprot.org/citations/23376074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23376074 | http://www.w3.org/2000/01/rdf-schema#comment | "E-cadherin expression is repressed by ZEB2/SIP1 while it is induced by KLF4. Independent data from the literature indicate that these two transcription factors could bind close to each other in the proximal region of the E-cadherin gene promoter. We have here explored a potential competition between ZEB2 and KLF4 for the binding to the E-cadherin promoter. We show an inverse correlation between ZEB2 expression levels and KLF4 recruitment on the E-cadherin promoter in three breast cancer cell lines and in A431/HA.ZEB2 cells in which ZEB2 expression is induced by doxycycline (DOX). We identified a region of the E-cadherin promoter bound by KLF4 which is necessary for the activation of the E-cadherin promoter activity after KLF4 overexpression. This region is localized between positions -28 and -10 and thus overlaps with one of the ZEB2 binding sites. Deleting the bipartite ZEB2 binding site results in increased KLF4 induced E-cadherin promoter activity. Taken together, our results suggest that E-cadherin expression in cancer cells is controlled by a balance between ZEB2 and KLF4 expression levels."xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2013.01.070"xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://purl.uniprot.org/core/author | "Winkler R."xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://purl.uniprot.org/core/author | "Gilles C."xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://purl.uniprot.org/core/author | "Berx G."xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://purl.uniprot.org/core/author | "Foidart J.M."xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://purl.uniprot.org/core/author | "Koopmansch B."xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23376074 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://purl.uniprot.org/core/pages | "652-657"xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://purl.uniprot.org/core/title | "Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression."xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://purl.uniprot.org/core/volume | "431"xsd:string |
| http://purl.uniprot.org/citations/23376074 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23376074 |
| http://purl.uniprot.org/citations/23376074 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23376074 |
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| http://purl.uniprot.org/uniprot/#_A0A0U2ZQU7-mappedCitation-23376074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23376074 |
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| http://purl.uniprot.org/uniprot/#_B3GN61-mappedCitation-23376074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23376074 |
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