| http://purl.uniprot.org/citations/23376458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23376458 | http://www.w3.org/2000/01/rdf-schema#comment | "Although HLA alleles are associated with type 1 diabetes, association with microvascular complications remains controversial. We tested HLA association with complications in multiplex type 1 diabetes families. Probands from 425 type 1 diabetes families from the Human Biological Data Interchange (HBDI) collection were analyzed. The frequencies of specific HLA alleles in patients with complications were compared with the frequencies in complications-free patients. The complications we examined were: retinopathy, neuropathy, and nephropathy. We used logistic regression models with covariates to estimate odds ratios. We found that the DRB1*03:01 allele is a protective factor for complications (OR=0.58; p=0.03), as is the DQA1*05:01-DQB1*02:01 haplotype found in linkage disequilibrium with DRB1*03:01 (OR=0.59; p=0.031). The DRB1*04:01 allele showed no evidence of association (OR=1.13; p=0.624), although DRB1*04:01 showed suggestive evidence when the carriers of the protective DRB1*03:01 were removed from the analysis. The class II DQA1*03:01-DQB1*03:02 haplotype was not associated with complications, but the class I allele B*39:06 (OR=3.27; p=0.008) suggested a strong positive association with complications. Our results show that in type 1 diabetes patients, specific HLA alleles may be involved in susceptibility to, or protection from, microvascular complications."xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2013.01.013"xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/author | "Noble J.A."xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/author | "Tomer Y."xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/author | "Greenberg D.A."xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/author | "Monti M.C."xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/author | "Lonsdale J.T."xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/author | "Stewart W.C."xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/author | "Corso B."xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/author | "Lipner E.M."xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/pages | "538-544"xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/title | "HLA class I and II alleles are associated with microvascular complications of type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://purl.uniprot.org/core/volume | "74"xsd:string |
| http://purl.uniprot.org/citations/23376458 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23376458 |
| http://purl.uniprot.org/citations/23376458 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23376458 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-23376458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23376458 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-23376458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23376458 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-23376458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23376458 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-23376458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23376458 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-23376458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23376458 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-23376458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23376458 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-23376458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23376458 |