| http://purl.uniprot.org/citations/23376919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23376919 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptors transduce their signals through the adaptor molecule MyD88 and members of the IL-1R-associated kinase family (IRAK-1, 2, M and 4). IRAK-1 and IRAK-2, known to form Myddosomes with MyD88-IRAK-4, mediate TLR7-induced TAK1-dependent NFκB activation. IRAK-M was previously known to function as a negative regulator that prevents the dissociation of IRAKs from MyD88, thereby inhibiting downstream signalling. However, we now found that IRAK-M was also able to interact with MyD88-IRAK-4 to form IRAK-M Myddosome to mediate TLR7-induced MEKK3-dependent second wave NFκB activation, which is uncoupled from post-transcriptional regulation. As a result, the IRAK-M-dependent pathway only induced expression of genes that are not regulated at the post-transcriptional levels (including inhibitory molecules SOCS1, SHIP1, A20 and IκBα), exerting an overall inhibitory effect on inflammatory response. On the other hand, through interaction with IRAK-2, IRAK-M inhibited TLR7-mediated production of cytokines and chemokines at translational levels. Taken together, IRAK-M mediates TLR7-induced MEKK3-dependent second wave NFκB activation to produce inhibitory molecules as a negative feedback for the pathway, while exerting inhibitory effect on translational control of cytokines and chemokines."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2013.2"xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Fukuda K."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Im J."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Kim T.W."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Yao P."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Zhou H."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Wan Y."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Thomas J."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Yin W."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Cui W."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "DiCorleto P.E."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Fox P.L."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Ma V."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Bulek K."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Wang J.A."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/author | "Zepp J."xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/23376919 | http://purl.uniprot.org/core/pages | "583-596"xsd:string |