| http://purl.uniprot.org/citations/23377137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23377137 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-14 is a seemingly non-apoptotic caspase involved in keratinocyte differentiation and cornification of the skin. Keratin-19 is an epithelial marker and a potential marker of epidermal stem cells that is expressed during human fetal skin development. We examined the immunohistochemical expression of caspase-14 in relation to CK-19 in the human fetal skin during development and perinatally, to assess their role in human skin maturation. Skin samples were received at autopsy. In the fetal epidermis, caspase-14 was predominantly expressed in the more differentiated layers, gradually disappearing from the basal layer toward term. By contrast, keratin-19 expression gradually decreased with epidermal maturation through gestation (rho = -0.949; p = 0.0001) and was a marker of the germinative layers. Keratin-19 was preserved in scarce basal cell nests at term and postnatally. Caspase-14 and keratin-19 were inversely expressed in the differentiating epidermal layers through gestation (p < 0.0001). Concerning the appendages, in hair follicles and sebaceous glands, caspase-14 located preferentially in the more differentiated layers of the inner root sheath, whereas keratin-19 was expressed in the outer sheath. Eccrine sweat glands showed a variable pattern of caspase-14 and keratin-19 expression. In conclusion, caspase-14 emerged as a marker of human skin differentiation during development, while keratin-19 marked the germinative epithelial layers in the fetal epidermis and appendages and possibly the nests of epidermal stem cells."xsd:string |
| http://purl.uniprot.org/citations/23377137 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00403-013-1319-8"xsd:string |
| http://purl.uniprot.org/citations/23377137 | http://purl.uniprot.org/core/author | "Konstantinidou A.E."xsd:string |
| http://purl.uniprot.org/citations/23377137 | http://purl.uniprot.org/core/author | "Aroni K."xsd:string |
| http://purl.uniprot.org/citations/23377137 | http://purl.uniprot.org/core/author | "Agrogiannis G."xsd:string |
| http://purl.uniprot.org/citations/23377137 | http://purl.uniprot.org/core/author | "Patsouris E.S."xsd:string |
| http://purl.uniprot.org/citations/23377137 | http://purl.uniprot.org/core/author | "Gkegkes I.D."xsd:string |
| http://purl.uniprot.org/citations/23377137 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23377137 | http://purl.uniprot.org/core/name | "Arch Dermatol Res"xsd:string |
| http://purl.uniprot.org/citations/23377137 | http://purl.uniprot.org/core/pages | "379-387"xsd:string |
| http://purl.uniprot.org/citations/23377137 | http://purl.uniprot.org/core/title | "Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development."xsd:string |
| http://purl.uniprot.org/citations/23377137 | http://purl.uniprot.org/core/volume | "305"xsd:string |
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