| http://purl.uniprot.org/citations/23379365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23379365 | http://www.w3.org/2000/01/rdf-schema#comment | "The prions (infectious proteins) of Saccharomyces cerevisiae are proteins acting as genes, by templating their conformation from one molecule to another in analogy to DNA templating its sequence. Most yeast prions are amyloid forms of normally soluble proteins, and a single protein sequence can have any of several self-propagating forms (called prion strains or variants), analogous to the different possible alleles of a DNA gene. A central issue in prion biology is the structural basis of this conformational templating process. The in-register parallel β sheet structure found for several infectious yeast prion amyloids naturally suggests an explanation for this conformational templating. While most prions are plainly diseases, the [Het-s] prion of Podospora anserina may be a functional amyloid, with important structural implications. Yeast prions are important models for human amyloid diseases in general, particularly because new evidence is showing infectious aspects of several human amyloidoses not previously classified as prions. We also review studies of the roles of chaperones, aggregate-collecting proteins, and other cellular components using yeast that have led the way in improving the understanding of similar processes that must be operating in many human amyloidoses."xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi301686a"xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/author | "Zhou A."xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/author | "Wickner R.B."xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/author | "Edskes H.K."xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/author | "Kelly A.C."xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/author | "Bateman D.A."xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/author | "Dayani Y."xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/author | "Gorkovskiy A."xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/pages | "1514-1527"xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/title | "Amyloids and yeast prion biology."xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/23379365 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23379365 |
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