| http://purl.uniprot.org/citations/23381944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23381944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23381944 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progression. Here, we show that a tRNA methyltransferase 9-like (hTRM9L/KIAA1456) mRNA is down-regulated in breast, bladder, colorectal, cervix and testicular carcinomas. In the aggressive SW620 and HCT116 colon carcinoma cell lines, hTRM9L is silenced and its re-expression and methyltransferase activity dramatically suppressed tumour growth in vivo. This growth inhibition was linked to decreased proliferation, senescence-like G0/G1-arrest and up-regulation of the RB interacting protein LIN9. Additionally, SW620 cells re-expressing hTRM9L did not respond to hypoxia via HIF1-α-dependent induction of GLUT1. Importantly, hTRM9L-negative tumours were highly sensitive to aminoglycoside antibiotics and this was associated with altered tRNA modification levels compared to antibiotic resistant hTRM9L-expressing SW620 cells. Our study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-α-dependent mechanisms. It also suggests that aminoglycoside antibiotics may be useful to treat hTRM9L-deficient tumours."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.org/dc/terms/identifier | "doi:10.1002/emmm.201201161"xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.org/dc/terms/identifier | "doi:10.1002/emmm.201201161"xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Su D."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Su D."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Dedon P.C."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Dedon P.C."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Begley T."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Begley T."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Begley U."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Begley U."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Chan C.T."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Chan C.T."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Endres L."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Endres L."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Patil A."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Patil A."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Aguirre-Ghiso J.A."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Aguirre-Ghiso J.A."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Avivar-Valderas A."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Avivar-Valderas A."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Estrada Y."xsd:string |
| http://purl.uniprot.org/citations/23381944 | http://purl.uniprot.org/core/author | "Estrada Y."xsd:string |