| http://purl.uniprot.org/citations/23382074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23382074 | http://www.w3.org/2000/01/rdf-schema#comment | "Although many functions and targets have been attributed to the histone and protein deacetylase SIRT1, a comprehensive analysis of SIRT1 binding proteins yielding a high-confidence interaction map has not been established. Using a comparative statistical analysis of binding partners, we have assembled a high-confidence SIRT1 interactome. Employing this method, we identified the deubiquitinating enzyme ubiquitin-specific protease 22 (USP22), a component of the deubiquitinating module (DUBm) of the SAGA transcriptional coactivating complex, as a SIRT1-interacting partner. We found that this interaction is highly specific, requires the ZnF-UBP domain of USP22, and is disrupted by the inactivating H363Y mutation within SIRT1. Moreover, we show that USP22 is acetylated on multiple lysine residues and that alteration of a single lysine (K129) within the ZnF-UBP domain is sufficient to alter interaction of the DUBm with the core SAGA complex. Furthermore, USP22-mediated recruitment of SIRT1 activity promotes the deacetylation of individual SAGA complex components. Our results indicate an important role of SIRT1-mediated deacetylation in regulating the formation of DUBm subcomplexes within the larger SAGA complex."xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00971-12"xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/author | "Zhang X.Y."xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/author | "Sinclair D.A."xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/author | "Bennett E.J."xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/author | "McMahon S.B."xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/author | "Armour S.M."xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/author | "Braun C.R."xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/pages | "1487-1502"xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/title | "A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex."xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23382074 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23382074 |
| http://purl.uniprot.org/citations/23382074 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23382074 |
| http://purl.uniprot.org/uniprot/Q53H80#attribution-971EBC835A0005D3ACEDFFA329358BE3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382074 |
| http://purl.uniprot.org/uniprot/P17544#attribution-971EBC835A0005D3ACEDFFA329358BE3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382074 |
| http://purl.uniprot.org/uniprot/Q9NWK9#attribution-971EBC835A0005D3ACEDFFA329358BE3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382074 |
| http://purl.uniprot.org/uniprot/P32121#attribution-971EBC835A0005D3ACEDFFA329358BE3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382074 |
| http://purl.uniprot.org/uniprot/Q8N163#attribution-971EBC835A0005D3ACEDFFA329358BE3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382074 |
| http://purl.uniprot.org/uniprot/Q86WX3#attribution-971EBC835A0005D3ACEDFFA329358BE3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382074 |
| http://purl.uniprot.org/uniprot/P16220#attribution-971EBC835A0005D3ACEDFFA329358BE3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23382074 |