| http://purl.uniprot.org/citations/23382195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23382195 | http://www.w3.org/2000/01/rdf-schema#comment | "B-cell lymphoma-6 protein (Bcl-6) is a corepressor for inflammatory mediators such as vascular cell adhesion molecule-1 and monocyte chemotactic protein-1 and -3, which function to recruit monocytes to vascular endothelial cells upon inflammation. Poly [ADP ribose] polymerase 1 (PARP-1) is proinflammatory, in part through its binding at the Bcl-6 intron 1 to suppress Bcl-6 expression. We investigated the mechanisms by which PARP-1 dissociates from the Bcl-6 intron 1, ultimately leading to attenuation of endothelial inflammation. Analysis of the PARP-1 primary sequence suggested that phosphorylation of PARP-1 Serine 177 (Ser-177) by AMP-activated protein kinase (AMPK) is responsible for the induction of Bcl-6. Our results show that AMPK activation with treatment of 5-aminoimidazole-4-carboxamide ribonucleotide, metformin, or pulsatile shear stress induces PARP-1 dissociation from the Bcl-6 intron 1, increases Bcl-6 expression, and inhibits expression of inflammatory mediators. Conversely, AMPKα suppression or knockdown produces the opposite effects. The results demonstrate an anti-infamatory pathway linking AMPK, PARP-1, and Bcl-6 in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1222051110"xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/author | "Martin M."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/author | "Chien S."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/author | "Shyy J.Y."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/author | "Johnson D.A."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/author | "King S."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/author | "Gongol B."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/author | "Woo B."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/author | "Peng I.C."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/author | "Marin T."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/pages | "3161-3166"xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/title | "AMPKalpha2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6."xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23382195 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23382195 |
| http://purl.uniprot.org/citations/23382195 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23382195 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX0-mappedCitation-23382195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23382195 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX03-mappedCitation-23382195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23382195 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY63-mappedCitation-23382195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23382195 |
| http://purl.uniprot.org/uniprot/#_P11103-mappedCitation-23382195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23382195 |
| http://purl.uniprot.org/uniprot/#_G8XUU5-mappedCitation-23382195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23382195 |