| http://purl.uniprot.org/citations/23382986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23382986 | http://www.w3.org/2000/01/rdf-schema#comment | "It is generally accepted that the immediately releasable pool is a group of readily releasable vesicles that are closely associated with voltage dependent Ca(2+) channels. We have previously shown that exocytosis of this pool is specifically coupled to P/Q Ca(2+) current. Accordingly, in the present work we found that the Ca(2+) current flowing through P/Q-type Ca(2+) channels is 8 times more effective at inducing exocytosis in response to short stimuli than the current carried by L-type channels. To investigate the mechanism that underlies the coupling between the immediately releasable pool and P/Q-type channels we transiently expressed in mouse chromaffin cells peptides corresponding to the synaptic protein interaction site of Cav2.2 to competitively uncouple P/Q-type channels from the secretory vesicle release complex. This treatment reduced the efficiency of Ca(2+) current to induce exocytosis to similar values as direct inhibition of P/Q-type channels via ω-agatoxin-IVA. In addition, the same treatment markedly reduced immediately releasable pool exocytosis, but did not affect the exocytosis provoked by sustained electric or high K(+) stimulation. Together, our results indicate that the synaptic protein interaction site is a crucial factor for the establishment of the functional coupling between immediately releasable pool vesicles and P/Q-type Ca(2+) channels."xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0054846"xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/author | "Zamponi G."xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/author | "Tedford H.W."xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/author | "Perez Bay A.E."xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/author | "Alvarez Y.D."xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/author | "Belingheri A.V."xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/author | "Javis S.E."xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/author | "Marengo F.D."xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/pages | "e54846"xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/title | "The immediately releasable pool of mouse chromaffin cell vesicles is coupled to P/Q-type calcium channels via the synaptic protein interaction site."xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23382986 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23382986 |
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