| http://purl.uniprot.org/citations/23384347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23384347 | http://www.w3.org/2000/01/rdf-schema#comment | "The successive events of shedding and regulated intramembrane proteolysis are known to comprise a fundamental biological process of type I and II membrane proteins (e.g. amyloid precursor protein, Notch receptor and pro-tumor necrosis factor-α). Some of the resulting fragments were shown to be involved in important intra- and extracellular signalling events. Although shedding of the human transferrin receptor-1 (TfR1) has been known for > 30 years and soluble TfR1 is an accepted diagnostic marker, the fate of the remaining N-terminal fragment (NTF) remains unknown. In the present study, we demonstrate for the first time that TfR1-NTF is subject to regulated intramembrane proteolysis and, using MALDI-TOF-TOF-MS, we have identified the cleavage site as being located C-terminal from Gly-84. We showed that the resulting C-terminal peptide is extracellularly released after regulated intramembrane proteolysis and it was detected as a monomer with an internal disulfide bridge. We further identified signal peptide peptidase-like 2a and mainly signal peptide peptidase-like 2b as being responsible for the intramembrane proteolysis of TfR1-NTF."xsd:string |
| http://purl.uniprot.org/citations/23384347 | http://purl.org/dc/terms/identifier | "doi:10.1111/febs.12176"xsd:string |
| http://purl.uniprot.org/citations/23384347 | http://purl.uniprot.org/core/author | "Fuchs H."xsd:string |
| http://purl.uniprot.org/citations/23384347 | http://purl.uniprot.org/core/author | "Fluhrer R."xsd:string |
| http://purl.uniprot.org/citations/23384347 | http://purl.uniprot.org/core/author | "Zahn C."xsd:string |
| http://purl.uniprot.org/citations/23384347 | http://purl.uniprot.org/core/author | "Kaup M."xsd:string |
| http://purl.uniprot.org/citations/23384347 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23384347 | http://purl.uniprot.org/core/name | "FEBS J"xsd:string |
| http://purl.uniprot.org/citations/23384347 | http://purl.uniprot.org/core/pages | "1653-1663"xsd:string |
| http://purl.uniprot.org/citations/23384347 | http://purl.uniprot.org/core/title | "The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b."xsd:string |
| http://purl.uniprot.org/citations/23384347 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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