| http://purl.uniprot.org/citations/23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23386617 | http://www.w3.org/2000/01/rdf-schema#comment | "RGC1 and RGC2 comprise a functional RalGAP complex (RGC) that suppresses RalA activity. The PI3-kinase/Akt signaling pathway activates RalA through phosphorylation-mediated inhibition of the RGC. Here we identify a novel phosphorylation-dependent interaction between 14-3-3 and the RGC. 14-3-3 binds to the complex through an Akt-phosphorylated residue, threonine 715, on RGC2. Interaction with 14-3-3 does not alter in vitro activity of the GTPase-activating protein complex. However, blocking the interaction between 14-3-3 and RGC2 in cells increases suppression of RalA activity by the RGC, suggesting that 14-3-3 inhibits the complex through a non-catalytic mechanism. Together, these data show that 14-3-3 negatively regulates the RGC downstream of the PI3-kinase/Akt signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.426106"xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://purl.uniprot.org/core/author | "Saltiel A.R."xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://purl.uniprot.org/core/author | "Chen X.W."xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://purl.uniprot.org/core/author | "Williams A."xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://purl.uniprot.org/core/author | "Uhm M."xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://purl.uniprot.org/core/author | "Leto D."xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23386617 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://purl.uniprot.org/core/pages | "9272-9283"xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://purl.uniprot.org/core/title | "Negative regulation of the RalGAP complex by 14-3-3."xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/23386617 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23386617 |
| http://purl.uniprot.org/citations/23386617 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23386617 |
| http://purl.uniprot.org/uniprot/#_E2I6G1-mappedCitation-23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23386617 |
| http://purl.uniprot.org/uniprot/#_D3YY41-mappedCitation-23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23386617 |
| http://purl.uniprot.org/uniprot/#_B3KVH4-mappedCitation-23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23386617 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D6-mappedCitation-23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23386617 |
| http://purl.uniprot.org/uniprot/#_A0A2P0XI22-mappedCitation-23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23386617 |
| http://purl.uniprot.org/uniprot/#_A0A3G2C3N5-mappedCitation-23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23386617 |
| http://purl.uniprot.org/uniprot/#_A0A8A2FPJ2-mappedCitation-23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23386617 |
| http://purl.uniprot.org/uniprot/#_A3KMH3-mappedCitation-23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23386617 |
| http://purl.uniprot.org/uniprot/#_A0A142IKA9-mappedCitation-23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23386617 |
| http://purl.uniprot.org/uniprot/#_B0LPE5-mappedCitation-23386617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23386617 |