| http://purl.uniprot.org/citations/23387390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23387390 | http://www.w3.org/2000/01/rdf-schema#comment | "We have defined three sets of HLA-DR3(+) haplotypes that provide maximum risk of type 1 disease development in Indians: (1) a diverse array of B8-DR3 haplotypes, (2) A33-B58-DR3 haplotype, and (3) A2-B50-DR3 occurring most predominantly in this population. Further analysis has revealed extensive diversity in B8-DR3 haplotypes, particularly at the HLA-A locus, in contrast to the single fixed HLA-A1-B8-DR3 haplotype (generally referred to as AH8.1) reported in Caucasians. However, the classical AH8.1 haplotype was rare and differed from the Caucasian counterpart at multiple loci. In our study, HLA-A26-B8-DR3 (AH8.2) was the most common B8-DR3 haplotype constituting >50% of the total B8-DR3 haplotypes. Further, A2-B8-DR3 contributed the maximum risk (RR = 48.7) of type 1 diabetes, followed by A2-B50-DR3 (RR = 9.4), A33-B58-DR3 (RR = 6.6), A24-B8-DR3 (RR = 4.5), and A26-B8-DR3 (RR = 4.2). Despite several differences, the disease-associated haplotypes in Indian and Caucasian populations share a frozen DR3-DQ2 block, suggesting a common ancestor from which multiple haplotypes evolved independently."xsd:string |
| http://purl.uniprot.org/citations/23387390 | http://purl.org/dc/terms/identifier | "doi:10.1111/nyas.12019"xsd:string |
| http://purl.uniprot.org/citations/23387390 | http://purl.uniprot.org/core/author | "Kumar N."xsd:string |
| http://purl.uniprot.org/citations/23387390 | http://purl.uniprot.org/core/author | "Kaur G."xsd:string |
| http://purl.uniprot.org/citations/23387390 | http://purl.uniprot.org/core/author | "Mehra N.K."xsd:string |
| http://purl.uniprot.org/citations/23387390 | http://purl.uniprot.org/core/author | "Kanga U."xsd:string |
| http://purl.uniprot.org/citations/23387390 | http://purl.uniprot.org/core/author | "Tandon N."xsd:string |
| http://purl.uniprot.org/citations/23387390 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23387390 | http://purl.uniprot.org/core/name | "Ann N Y Acad Sci"xsd:string |
| http://purl.uniprot.org/citations/23387390 | http://purl.uniprot.org/core/pages | "91-96"xsd:string |
| http://purl.uniprot.org/citations/23387390 | http://purl.uniprot.org/core/title | "Genomic evaluation of HLA-DR3+ haplotypes associated with type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/23387390 | http://purl.uniprot.org/core/volume | "1283"xsd:string |
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