| http://purl.uniprot.org/citations/23389633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23389633 | http://www.w3.org/2000/01/rdf-schema#comment | "Multiple Rabs are associated with secretory granules/vesicles, but how these GTPases are coordinated to promote regulated exocytosis is not well understood. In bladder umbrella cells a subapical pool of discoidal/fusiform-shaped vesicles (DFVs) undergoes Rab11a-dependent regulated exocytosis in response to bladder filling. We show that Rab11a-associated vesicles are enmeshed in an apical cytokeratin meshwork and that Rab11a likely acts upstream of Rab8a to promote exocytosis. Surprisingly, expression of Rabin8, a previously described Rab11a effector and guanine nucleotide exchange factor for Rab8, stimulates stretch-induced exocytosis in a manner that is independent of its catalytic activity. Additional studies demonstrate that the unconventional motor protein myosin5B motor (Myo5B) works in association with the Rab8a-Rab11a module to promote exocytosis, possibly by ensuring transit of DFVs through a subapical, cortical actin cytoskeleton before fusion. Our results indicate that Rab11a, Rab8a, and Myo5B function as part of a network to promote stretch-induced exocytosis, and we predict that similarly organized Rab networks will be common to other regulated secretory pathways."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e12-08-0568"xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/author | "Goldenring J.R."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/author | "Peranen J."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/author | "Gallo L.I."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/author | "Khandelwal P."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/author | "Apodaca G."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/author | "Clayton D.R."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/author | "Lukianov S."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/author | "Ruiz W.G."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/author | "Prakasam H.S."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/author | "van Roekel D."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/pages | "1007-1019"xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/title | "A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells."xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/23389633 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23389633 |
| http://purl.uniprot.org/citations/23389633 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23389633 |
| http://purl.uniprot.org/uniprot/#_P70569-mappedCitation-23389633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23389633 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZST3-mappedCitation-23389633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23389633 |
| http://purl.uniprot.org/uniprot/#_A6KRF7-mappedCitation-23389633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23389633 |
| http://purl.uniprot.org/uniprot/#_A6KRF8-mappedCitation-23389633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23389633 |
| http://purl.uniprot.org/uniprot/#_A6KRF9-mappedCitation-23389633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23389633 |