| http://purl.uniprot.org/citations/23390291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23390291 | http://www.w3.org/2000/01/rdf-schema#comment | "Complement receptor 1-related gene/protein y (Crry) and decay-accelerating factor (DAF) are two murine membrane C3 complement regulators with overlapping functions. Crry deletion is embryonically lethal whereas DAF-deficient mice are generally healthy. Crry(-/-)DAF(-/-) mice were viable on a C3(-/-) background, but platelets from such mice were rapidly destroyed when transfused into C3-sufficient mice. In this study, we used the cre-lox system to delete platelet Crry in DAF(-/-) mice and studied Crry/DAF-deficient platelet development in vivo. Rather than displaying thrombocytopenia, Pf4-Cre(+)-Crry(flox/flox) mice had normal platelet counts and their peripheral platelets were resistant to complement attack. However, chimera mice generated with Pf4-Cre(+)-Crry(flox/flox) bone marrows showed platelets from C3(-/-) but not C3(+/+) recipients to be sensitive to complement activation, suggesting that circulating platelets in Pf4-Cre(+)-Crry(flox/flox) mice were naturally selected in a complement-sufficient environment. Notably, Pf4-Cre(+)-Crry(flox/flox) mouse platelets became complement susceptible when factor H function was blocked. Examination of Pf4-Cre(+)-Crry(flox/flox) mouse bone marrows revealed exceedingly active thrombopoiesis. Thus, under in vivo conditions, Crry/DAF deficiency on platelets led to abnormal platelet turnover, but peripheral platelet count was compensated for by increased thrombopoiesis. Selective survival of Crry/DAF-deficient platelets aided by factor H protection and compensatory thrombopoiesis demonstrates the cooperation between membrane and fluid phase complement inhibitors and the body's ability to adaptively respond to complement regulator deficiencies."xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1202536"xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/author | "Kim D."xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/author | "Miwa T."xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/author | "Song W.C."xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/author | "Barata L."xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/author | "Mohammed I."xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/pages | "2886-2895"xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/title | "Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack."xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://purl.uniprot.org/core/volume | "190"xsd:string |
| http://purl.uniprot.org/citations/23390291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23390291 |
| http://purl.uniprot.org/citations/23390291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23390291 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXH8-mappedCitation-23390291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23390291 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXN9-mappedCitation-23390291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23390291 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXR6-mappedCitation-23390291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23390291 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY75-mappedCitation-23390291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23390291 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SG88-mappedCitation-23390291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23390291 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVT1-mappedCitation-23390291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23390291 |
| http://purl.uniprot.org/uniprot/#_E9PDY4-mappedCitation-23390291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23390291 |
| http://purl.uniprot.org/uniprot/#_A0A346RCT4-mappedCitation-23390291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23390291 |
| http://purl.uniprot.org/uniprot/#_A0A346RD54-mappedCitation-23390291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23390291 |