| http://purl.uniprot.org/citations/23393141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23393141 | http://www.w3.org/2000/01/rdf-schema#comment | "Low dietary intake of β-carotene is associated with chronic disease and vitamin A deficiency. β-Carotene is converted to vitamin A in the intestine by the enzyme β-carotene-15,15'-monoxygenase (BCMO1) to support vision, reproduction, immune function, and cell differentiation. Considerable variability for this key step in vitamin A metabolism, as reported in the human population, could be related to genetics and individual vitamin A status, but it is unclear how these factors influence β-carotene metabolism and vitamin A homeostasis. Here we show that the intestine-specific transcription factor ISX binds to the Bcmo1 promoter. Moreover, upon induction by the β-carotene derivative retinoic acid, this ISX binding decreased expression of a luciferase reporter gene in human colonic CaCo-2 cells indicating that ISX acts as a transcriptional repressor of BCMO1 expression. Mice deficient for this transcription factor displayed increased intestinal BCMO1 expression and produced significantly higher amounts of vitamin A from supplemental β-carotene. The ISX binding site in the human BCMO1 promoter contains a common single nucleotide polymorphism that is associated with decreased conversion rates and increased fasting blood levels of β-carotene. Thus, our study establishes ISX as a critical regulator of vitamin A production and provides a mechanistic explanation for how both genetics and diet can affect this process."xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.444240"xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/author | "Taylor D."xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/author | "von Lintig J."xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/author | "Shivdasani R.A."xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/author | "Amengual J."xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/author | "Lobo G.P."xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/author | "Baus D."xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/pages | "9017-9027"xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/title | "Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX."xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/23393141 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23393141 |
| http://purl.uniprot.org/citations/23393141 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23393141 |
| http://purl.uniprot.org/uniprot/#_B1Q2M1-mappedCitation-23393141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23393141 |
| http://purl.uniprot.org/uniprot/#_A1A546-mappedCitation-23393141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23393141 |
| http://purl.uniprot.org/uniprot/#_B1B1S6-mappedCitation-23393141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23393141 |
| http://purl.uniprot.org/uniprot/#_Q2M1V0-mappedCitation-23393141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23393141 |
| http://purl.uniprot.org/uniprot/A1A546 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23393141 |
| http://purl.uniprot.org/uniprot/B1B1S6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23393141 |
| http://purl.uniprot.org/uniprot/Q2M1V0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23393141 |
| http://purl.uniprot.org/uniprot/B1Q2M1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23393141 |