| http://purl.uniprot.org/citations/23395175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23395175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23395175 | http://www.w3.org/2000/01/rdf-schema#comment | "Posttranslational modifications play central roles in myriad biological pathways including circadian regulation. We employed a circadian proteomic approach to demonstrate that circadian timing of phosphorylation is a critical factor in regulating complex GSK3β-dependent pathways and identified O-GlcNAc transferase (OGT) as a substrate of GSK3β. Interestingly, OGT activity is regulated by GSK3β; hence, OGT and GSK3β exhibit reciprocal regulation. Modulating O-GlcNAcylation levels alter circadian period length in both mice and Drosophila; conversely, protein O-GlcNAcylation is circadianly regulated. Central clock proteins, Clock and Period, are reversibly modified by O-GlcNAcylation to regulate their transcriptional activities. In addition, O-GlcNAcylation of a region in PER2 known to regulate human sleep phase (S662-S674) competes with phosphorylation of this region, and this interplay is at least partly mediated by glucose levels. Together, these results indicate that O-GlcNAcylation serves as a metabolic sensor for clock regulation and works coordinately with phosphorylation to fine-tune circadian clock."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2012.12.017"xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2012.12.017"xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Burlingame A.L."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Burlingame A.L."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Shokat K.M."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Shokat K.M."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Chalkley R.J."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Chalkley R.J."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Fu Y.H."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Fu Y.H."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Ptacek L.J."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Ptacek L.J."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Baer K."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Baer K."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Allen J.J."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Allen J.J."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Kaasik K."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Kaasik K."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Kissel H."xsd:string |
| http://purl.uniprot.org/citations/23395175 | http://purl.uniprot.org/core/author | "Kissel H."xsd:string |